| 应用 |
Bavisant Hcl (JNJ-31001074) is a highly selective, orally active antagonist of the human H3 receptor with a novel mechanism of action, involving wakefulness and cognition, with potential as a treatment for ADHD. IC50 Value: Target: H3 receptorin vitro: Bavisant completed a phase II ADHD trial, but no results have been reported.in vivo: Mean change from baseline in the total ADHD-RS-IV score at day 42 (primary efficacy endpoint) was -8.8 in the placebo group versus -9.3, -11.2 and -12.2 in the bavisant 1•mg/day, 3•mg/day and 10•mg/day groups, respectively; the change in the 10•mg/day group was not statistically superior to placebo (p=0.161), and hence statistical comparisons of the 1•mg/day and 3•mg/day groups with placebo based on a step-down closed testing procedure were not performed .Clinical trial: A Study to Characterize the Pharmacokinetics and Effect of Food on JNJ-31001074 in Healthy Volunteers. |
