| 名称 |
anti- AFF4 antibody |
| 来源 |
Rabbit |
| 应用 |
ELISA, WB, IHC |
| 反应 |
Human, Mouse, Rat |
| 稀释范围 |
WB: 1:200-1:2000 |
| 克隆 |
polyclonal |
| 蛋白号 |
Q9UHB7 |
| 分子质量 |
150 kDa |
| 纯化 |
Immunogen affinity purified |
| 纯度 |
≥95% as determined by SDS-PAGE |
| 状态 |
liquid |
| 免疫原 |
AF4/FMR2 family, member 4 |
| 亚型 |
IgG |
| 存储 |
PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| 别名 |
AF4/FMR2 family member 4, AF4/FMR2 family, member 4, AF5Q31, AFF4, MCEF, Protein AF 5q31 |
| 背景介绍 |
Key component of the super elongation complex(SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. In the SEC complex, AFF4 acts as a central scaffold that recruits other factors through direct interactions with ELL proteins(ELL, ELL2 or ELL3) and the P-TEFb complex. In case of infection by HIV-1 virus, the SEC complex is recruited by the viral Tat protein to stimulate viral gene expression. |
